Researchers in a cell-scale laboratory study investigated the effect of extracts of three types of Iranian olives in protecting nerve cells against Parkinson’s.
According to ISNA, Parkinson’s disease is one of the diseases of the nervous system. These types of diseases are incurable and have a growing prevalence in different societies. In Parkinson’s disease, with the loss of nerve cells, especially neurons in the corpus luteum, the patient experiences irreversible motor and perceptual complications..
This neuronal damage and death is associated with the accumulation of alpha-synuclein proteins. The function of these proteins is “alpha-synuclein» It is not well known, but studies have shown that they are involved in the release of neurotransmitters, and that the deposition and accumulation of these proteins in neurons is associated with Parkinson’s disease..
Studies also show that some toxins can cause Parkinson’s disease by causing stressful conditions for nerve cells. Rotenone toxin, as a neurotoxin, kills nerve cells and can cause Parkinson’s disease if exposed for a long time..
Given the importance of this issue; Genetic and biotechnology researchers studied the effect of extracts of three Iranian olive cultivars on engineered cells of Parkinson’s disease.
To conduct this study, the researchers used rotenone to induce overexpression of the alpha-synuclein protein in neurons to use as model cells in Parkinson’s disease. These neurons reacted strongly to rotenone treatment, and in addition to causing toxicity, the length of the neurite filaments was reduced by rotenone treatment..
Also in this study, the effect of extracts of three types of Iranian olives including oily olives, yellow olives and insane olives on this type of cells was investigated..
The results of this study showed that the extract of these olives can significantly protect nerve cells against rotenone-induced toxicity and the amount of oxygen free radicals inside this cell was significantly reduced..
Purification of active radicals showed that these extracts could play a protective role for neurons through this mechanism. However, according to the researchers in this study; Due to the different behavior of extracts in the extracellular environment, more complex mechanisms seem to be involved in their protective role in neurons..
“The results of this study show that the original Iranian cultivars of olive oil and yellow olive can significantly increase the survival of sensitive neurons, even in the presence of rotenone toxin,” the researchers said..
The researchers believe that due to the native nature of these olive cultivars, the results could be very valuable in future studies of Parkinson’s disease..
In conducting this research, Dina Morshedi, Farhang Ali Akbari, Saha Parsafar, Faezeh Dehghani Esmatabadi and Alireza Amiri Nodijeh; Researchers at the National Institute of Genetic Engineering and Biotechnology of Iran and Hossein Mohammad Beigi from the Nanoscience Interdisciplinary Center (iNANO), Aarhus University of Denmark participated.
The findings of this study were published in the summer of this year as a scientific article entitled “Inhibition of rotenone toxicity in Parkinson’s disease cell model with methanolic extract of Iranian olives” in the Journal of Cellular and Molecular Research (Iranian Journal of Biology).